Mango leaves have been used by traditional medicine of a number of peoples for centuries. The key biological substance in them is a polyphenol called mangiferin. Mangiferin commonly used as antioxidant for medical purposes.
Mangiferin inhibited the hydroxyl radicals by 84.3 % at 37 °С and 79.8 % at 80°С, as it showed a higher antioxidant activity than quercetine.
Studies have suggested that Mangiferin also has an in vitro anticancer effect in cellular lines of acute myeloid leukemia. It was also reported Mangiferin as a promising natural product with benefits as analgesic, anti-sclerotic, antiviral, cardio and hepatoprotective, anti-allergic, monoamine oxygenase (MAO) inhibitor, and protector against UV radiation.
These polyphenols of mangiferin exhibit antioxidant properties and tend to decrease the oxygen-free radicals, thereby reducing the DNA damage. Indeed, its capability to modulate several key inflammatory pathways undoubtedly helps installing the progression of carcinogenesis.
Pharmacological properties of mangiferin
